Renin content of systemic blood of rats with desoxycorticosterone and metacorticoid hypertension.

IT HAS BEEN demonstrated in different laboratories that chronic treatment with desoxycorticosterone acetate (DCA) induces in rats a particular type of hypertensive disease.' Observations by Friedman and Friedman, Friedman, Friedman and Nakashima, Prado and Herbert-Carrington, Magaldi and Prado showed that following abrupt interruption of the desoxycorticosterone treatment, from 30 to 40 per cent of the animals become permanently hypertensive. These results, with a still higher incidence of permanent hypertension, were confirmed by Green and colleagues. The later phase of desoxycorticosterone hypertension has been named selfsustained, residual and postdesoxycorticoslerone; Selyc and Horava have lately suggested the name melahormonal or metacorticoid. hypertension. Although an extremely informative study of desoxycorticosterone and metacorticoid hypertension has been recently reported by Green